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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
36.36
Human Site:
S387
Identified Species:
57.14
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
S387
N
M
T
L
Q
P
K
S
F
G
S
T
C
Q
L
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
S416
N
M
T
L
Q
P
K
S
F
G
S
K
C
Q
L
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
S402
N
M
T
L
Q
P
K
S
F
G
S
K
C
Q
L
Dog
Lupus familis
XP_537646
1532
174610
S387
N
M
T
L
Q
V
K
S
F
G
S
T
C
Q
L
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
S386
N
M
T
L
Q
A
K
S
F
G
S
T
C
Q
L
Rat
Rattus norvegicus
P41516
1526
173202
S385
N
M
T
L
Q
A
K
S
F
G
S
T
C
Q
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
S415
N
M
T
L
Q
A
K
S
F
G
S
K
C
Q
L
Chicken
Gallus gallus
O42130
1553
174974
S388
N
M
T
L
Q
A
K
S
F
G
S
T
C
K
L
Frog
Xenopus laevis
NP_001082502
1579
178601
S385
N
M
T
L
Q
S
K
S
F
G
S
K
C
T
L
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
N386
N
M
T
L
Q
Q
K
N
F
G
S
A
C
S
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
G368
N
M
T
L
Q
Q
K
G
F
G
S
K
C
T
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
Q422
T
M
T
L
Q
Q
K
Q
F
G
S
T
C
V
L
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
K412
N
M
T
L
Q
I
K
K
F
G
S
T
C
K
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
S389
T
L
T
L
R
Q
S
S
F
G
S
K
C
E
L
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
D376
Q
L
T
T
R
V
K
D
F
G
S
R
C
E
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
93.3
93.3
93.3
N.A.
93.3
93.3
N.A.
86.6
86.6
80
73.3
N.A.
73.3
N.A.
73.3
80
P-Site Similarity:
100
93.3
93.3
93.3
N.A.
93.3
93.3
N.A.
86.6
93.3
80
80
N.A.
73.3
N.A.
73.3
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
53.3
40
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
27
0
0
0
0
0
7
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
100
0
0
% C
% Asp:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
14
0
% E
% Phe:
0
0
0
0
0
0
0
0
100
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
7
0
100
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
7
% I
% Lys:
0
0
0
0
0
0
94
7
0
0
0
40
0
14
0
% K
% Leu:
0
14
0
94
0
0
0
0
0
0
0
0
0
0
94
% L
% Met:
0
87
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
80
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
20
0
0
0
0
0
0
0
0
0
% P
% Gln:
7
0
0
0
87
27
0
7
0
0
0
0
0
47
0
% Q
% Arg:
0
0
0
0
14
0
0
0
0
0
0
7
0
0
0
% R
% Ser:
0
0
0
0
0
7
7
67
0
0
100
0
0
7
0
% S
% Thr:
14
0
100
7
0
0
0
0
0
0
0
47
0
14
0
% T
% Val:
0
0
0
0
0
14
0
0
0
0
0
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _